Supported by NIAID
 

Recent Publications


Rheumatoid arthritis: a view of the current genetic landscape.
Coenen MJ, Gregersen PK. Rheumatoid arthritis: a view of the current genetic landscape. Coenen MJ, Gregersen PK.

Genes Immun. 2009 Mar;10(2):101-11.
http://www.ncbi.nlm.nih.gov/pubmed/18987647  


Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
Silverberg MS, Cho JH, Rioux JD, McGovern DP, Wu J, Annese V, Achkar JP, Goyette P, Scott R, Xu W, Barmada MM, Klei L, Daly MJ, Abraham C, Bayless TM, Bossa F, Griffiths AM, Ippoliti AF, Lahaie RG, Latiano A, Paré P, Proctor DD, Regueiro MD, Steinhart AH, Targan SR, Schumm LP, Kistner EO, Lee AT, Gregersen PK, Rotter JI, Brant SR, Taylor KD, Roeder K, Duerr RH.

Nat Genet. 2009 Feb;41(2):216-20.
http://www.nature.com/ng/journal/v41/n2/abs/ng.275.html  


Analysis and application of European genetic substructure using 300 K SNP information. PLoS
Tian C, Plenge RM, Ransom M, Lee A, Villoslada P, Selmi C, Klareskog L, Pulver AE, Qi L, Gregersen PK, Seldin MF

Genet. 2008 Jan;4(1)
http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0040005  


Association of Systemic Lupus Erythematosus with C8orf13-BLK and ITGAM-ITGAX.
Hom G, Graham RR, Modrek B, Taylor KE, Ortmann W, Garnier S, Lee AT, Chung SA, Ferreira RC, Pant PV, Ballinger DG, Kosoy R, Demirci FY, Kamboh MI, Kao AH, Tian C, Gunnarsson I, Bengtsson AA, Rantapää-Dahlqvist S, Petri M, Manzi S, Seldin MF, Rönnblom L, Syvänen AC, Criswell LA, Gregersen PK, Behrens TW.

N Engl J Med. 2008 Jan 20
http://content.nejm.org/cgi/content/full/NEJMoa0707865  


Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus. PLoS
Taylor KE, Remmers EF, Lee AT, Ortmann WA, Plenge RM, Tian C, Chung SA, Nititham J, Hom G, Kao AH, Demirci FY, Kamboh MI, Petri M, Manzi S, Kastner DL, Seldin MF, Gregersen PK, Behrens TW, Criswell LA.

Genet. 2008 May 30;4(5):
http://www.plosgenetics.org/article/info:doi%2F10.1371%2Fjournal.pgen.1000084  


Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in Rheumatoid Arthritis.
Liu C, Batliwalla F, Li W, Lee A, Roubenoff R, Beckman E, Khalili H, Damle A, Kern M, Plenge RM, Coenen M, Behrens TW, Furie R, Carulli JP, Gregersen PK.

Mol Med. 2008 Jul 10. PMC2443997.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2443997  


Analysis of East Asia genetic substructure using genome-wide SNP arrays.
Tian C, Kosoy R, Lee A, Ransom M, Belmont JW, Gregersen PK, Seldin MF.

PLoS ONE. 2008;3(12):e3862.
http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0003862  


Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD, Padyukov L, Kurreeman FA, Chang M, Catanese JJ, Ding B, Wong S, van der Helm-van Mil AH, Neale BM, Coblyn J, Cui J, Tak PP, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Criswell LA, Amos CI, Seldin MF, Kastner DL, Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TW, Shadick NA, Weinblatt ME, de Vries N, Worthington J, Seielstad M, Toes RE, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly MJ, Plenge RM.

Nat Genet. 2008 Oct;40(10):1216-23. Epub 2008 Sep 14.
http://www.nature.com/ng/journal/v40/n10/full/ng.233.html  


Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.
Musone SL, Taylor KE, Lu TT, Nititham J, Ferreira RC, Ortmann W, Shifrin N, Petri MA, Ilyas Kamboh M, Manzi S, Seldin MF, Gregersen PK, Behrens TW, Ma A, Kwok PY, Criswell LA.

Nat Genet. 2008 , 40:1062-4
http://www.nature.com/ng/journal/v40/n9/full/ng.202.html  


STAT4 and Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus.
Remmers EF, Plenge RM, Lee AT, Graham RR, Hom G, BehrensTW, de Bakker PIW., Le JM, Lee H-S, Batliwalla F, Li W, Masters SL, Booty MG, Carulli JP, Padyukov L, Alfredsson L, Klareskog L, Chen WV, Amos CI, Criswell LA, Seldin MF, Kastner DL and Gregersen PK.

New England J. Med., 2007, 357:977-986
http://nejm.highwire.org/cgi/content/abstract/357/10/977  


Whole genome association study in rheumatoid arthritis identifies TRAF1-C5 as a new susceptibility locus.
Plenge RM, Sielsted M, Padyukov L, Lee AT, Remmers EF, Liew A, Khalili H, Chandrasekaran A, Davies L, Alfredsson L, Li W, Liu C, Tian C, Chen WV, Altshuler D, Carulli JP, Ph.D., Criswell LA, Amos CI, Seldin MF, Kastner DL, Klareskog L, Gregersen PK.

New England J. Med.,2007, 357:1199-209
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2636867  


Association of STAT4 with rheumatoid arthritis in the Korean population.
Lee HS, Remmers EF, Le JM, Kastner DL, Bae SC, Gregersen PK.

Mol Med. 2007 13:455-60
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2014726  


STAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus
Elaine F. Remmers, Ph.D., Robert M. Plenge, M.D., Ph.D., Annette T. Lee, Ph.D., Robert R. Graham, Ph.D., Geoffrey Hom, Ph.D., Timothy W. Behrens, M.D., Paul I.W. de Bakker, Ph.D., Julie M. Le, B.S., Hye-Soon Lee, M.D., Ph.D., Franak Batliwalla, Ph.D., Wentian Li, Ph.D., Seth L. Masters, Ph.D., Matthew G. Booty, B.S., John P. Carulli, Ph.D., Leonid Padyukov, M.D., Ph.D., Lars Alfredsson, Ph.D., Lars Klareskog, M.D., Ph.D., Wei V. Chen, M.S., Christopher I. Amos, Ph.D., Lindsey A. Criswell, M.D., M.P.H., Michael F. Seldin, M.D., Ph.D., Daniel L. Kastner, M.D., Ph.D., and Peter K. Gregersen, M.D.

N Engl J Med 2007;357:xxx-xx. - PDF -  


TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study
Robert M. Plenge, M.D., Ph.D., Mark Seielstad, Ph.D., Leonid Padyukov, M.D., Ph.D., Annette T. Lee, Ph.D., Elaine F. Remmers, Ph.D., Bo Ding, Ph.D., Anthony Liew, M.S., Houman Khalili, B.S., Alamelu Chandrasekaran, Ph.D., Leela R.L. Davies, B.S., Wentian Li, Ph.D., Adrian K.S. Tan, M.Sc., Carine Bonnard, M.Sc., Rick T.H. Ong, M.Sc., Anbupalam Thalamuthu, Ph.D., Sven Pettersson, M.D., Ph.D., Chunyu Liu, Ph.D., Chao Tian, B.S., Wei V. Chen, M.S., John P. Carulli, Ph.D., Evan M. Beckman, M.D., David Altshuler, M.D., Ph.D., Lars Alfredsson, Ph.D., Lindsey A. Criswell, M.D., M.P.H., Christopher I. Amos, Ph.D., Michael F. Seldin, M.D., Ph.D., Daniel L. Kastner, M.D., Ph.D.,

N Engl J Med 2007;357. - PDF -  


Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) Collection: the PTPN22 620W Allele Associates with Multiple Autoimmune Phenotypes
Lindsey A. Criswell, Kirsten A. Pfeiffer, Raymond F. Lum , Bonnie Gonzales, Jill Novitzke , Marlena Kern, Kathy L. Moser, Ann B. Begovich , Victoria E. H. Carlton, Wentian Li, Annette T. Lee, Ward Ortmann , Timothy W. Behrens, and Peter K. Gregersen

Am. J. Hum. Genet. 76:000-000, 2005 - PDF -  

Do Any of These Autoimmune Diseases Run in Your Family?

Rheumatoid Arthritis

Multiple Sclerosis

Lupus

Autoimmune Thyroid Disease (Graves' or Hashimoto's)


Type I Diabetes (Insulin Dependent)





MADGC Resources for the Scientific Community